Translational Research Related Content

Irritability is the most common reason children are brought for psychiatric evaluation. It is a diagnostic criterion or associated symptom for multiple diagnoses listed in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Over the past 20 years, much has been learned...

An international team led by investigators at McLean Hospital analyzed the genes expressed in approximately 575,000 individual cells from the brains of people with and without post-traumatic stress and major depressive disorders (PTSD and MDD), revealing new insights into the mechanisms behind the...

Much research on treatment of substance use disorders (SUDs) focuses on reducing symptoms like depression and cravings. However, a growing body of literature examines the role of grit, gratitude, happiness, and other positive psychological constructs, including optimism. Dispositional optimism—the...

Cell therapy holds promise as a new treatment for Parkinson’s disease, but in many trials to date, most transplanted dopamine cells have failed to survive, raising a fundamental obstacle. Recent advancements led by researchers at McLean Hospital and Massachusetts General Hospital could change this...

Former professional football players who reported experiencing concussion symptoms during their playing careers were found to perform worse on a battery of cognitive tests than nonplayers, according to a study led by Mass General Brigham investigators from McLean Hospital and Spaulding...