Nikolaos P. Daskalakis, MD, PhD, director of the Neurogenomics and Translational Bioinformatics Laboratory at McLean Hospital, is part of an international research collaboration that has been awarded a $1.14 million grant from the prestigious Human Frontier Science Program (HFSP).
- An international team including McLean Hospital’s Nikolaos P. Daskalakis, MD, PhD, has been awarded a multimillion-dollar research grant from the prestigious International Human Frontier Science Program (HFSP) Organization
- The funds will help investigators study how the energy-producing mitochondria communicate with the cell nucleus—a process that’s critical to health
Daskalakis’s group is one of 32 winning research teams in a global competition that received 716 grant applications.
The grant, worth $380,000 per year over the next three years, will allow Daskalakis and his collaborators from diverse scientific fields—including Konstantinos Lefkimmiatis, PhD, of the University of Pavia in Italy and Brigitte Städler, PhD, of the University of Aarhus in Denmark—to study how the energy-producing portions of a cell, called mitochondria, communicate with the cell nucleus, which stores a cell’s genetic information.
“We want to understand the ability of the cell to communicate its energy needs to the mitochondria, but also to perceive and respond to the requirements of the mitochondria. Interruptions in communication between mitochondria and the nucleus disrupt the homeostatic balance of a cell and are the basis of many pathologies, such as tumors and degenerative diseases,” Daskalakis explained.